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Results Local treatment of CCT could significantly decrease BG levels, stimulate insulin secretion and improve the function of pancreatic beta cells. It also decreased serum urea levels comparing to pre-treatment levels (p less then 0.05) but there was no significant change in creatinine levels, lipid profiles, hepatic enzymes, micro-albuminuria, and other insulin sensitivity indexes. Conclusion This study demonstrated that the CCT plant can also have systemic therapeutic effects on type II diabetic patients through dermal absorption.Back