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The DROP mathematical formula tends to make Tcpo2 results separate from the absolute pO2 beginning values, improving dependability of Ex-TcpO2 when compared with the RPI. Since then, Ex-TcpO2 has been of restored interest. The current paper addresses the physiology of Ex-TcpO2, interpretation of their outcomes, and common misconceptions about its usage. Glioblastoma (GBM) would be the most malignant mind tumors in people while having a tremendously poor prognosis. Temozolomide (TMZ