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CS strongly stimulated the proliferation of KFs, however NFs. The analysis of this intracellular sign transduction path disclosed that the stimulation effectation of CS on KF expansion was due to the activation associated with the necessary protein kinase B (AKT) pathway and that integrin α1 had been responsible for this occurrence. We revealed that CS probably triggers the AKT path through integrin to induce KF proliferation. CS is a novel clinical therapeutic target in keloids.In this research, graphene/silver nanowire (Gr/AgNW)-based, F
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