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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression If a person is suffering from both ADHD and depression or anxiety, treating the first disorder can improve the other. Mental health professionals usually prescribe antidepressants or stimulants for depression along with an ADHD medication. Wellbutrin (bupropion) and Effexor, (venlafaxine), are the two most common antidepressants that are prescribed for ADHD "off-label". These medications increase levels of the neurotransmitters norepinephrine and dopamine. They