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Finally, genetic analyses demonstrated that PIF4 and PIF5 are epistatic to PRRs in the regulation of photoperiodic hypocotyl growth. Collectively, we propose that, upon perceiving daylength information, PRRs cooperate with EC to directly repress PIF4 and PIF5 transcription together with their post-translational regulation on PIFs activities, thus forming a complex regulatory network to mediate circadian clock-regulated photoperiodic growth. copyright, serif 2020 American Society of Plant Biologists. All rights reserved.OBJECTIVE Debate