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Chymostatins are hydrophobic tetrapeptide aldehydes from streptomycetes, e.g., S. lavendulae and S. hygroscopicus, that reverse chymosin-mediated angiotensin activation and prevent other serine and cysteine proteases. Chymotrypsin and papain had been both inhibited by the SPIac substances when you look at the reduced nanomolar range. SPIac differs from the characterized chymostatins because of the trade of phenylalanine for tyrosine. The crystal c