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Manufacturing hypoimmunogenic iPSCs by inactivation or over-expression during the hereditary level and then arming the derived cells with vehicle have emerged as a form of "off-the-shelf" strategy to remove tumefaction cells efficiently and safely in a broader selection of patients. This analysis describes the reasonability, feasibility, superiority, and drawbacks of these methods, summarizes the present methods and appropriate research progress, and offers ideas into the poss