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Mean changes from week 0 in ADHD-RS-IV complete and subscale scores and CAARS subscale scores were substantially enhanced in previous placebo or GXR patients and new patients at last observance (p .0001), together with percentage of patients with truly or much improved CGI-I and PGI-I scores increased. There were no significant safety concerns during lasting GXR management in grownups with ADHD. After long-term therapy, patients had significant improvements from baseline in ADHD signs, QoL