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Coronavirus disease 2019 (COVID-19) is affecting the whole world and threatening human health. We aim to investigate the immunological characteristics of monocytes in critical patients with COVID-19. The number and immune status of monocytes were detected by flow cytometry in 32 COVID-19 patients and 18 healthy individuals. In critical patients with COVID-19, the absolute number of total monocytes and CD16 monocytes was significantly decreased but CD16 pro-inflammatory monocytes was increased compared to healthy controls. Antigen presen