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The biomarker potential of three miRNAs (miR-126, miR-19a, and miR-41 was confirmed by qRT-PCR, with significantly increased quantities in serum of AMD patients compared with healthy controls. Increased quantities of miR-126, miR-410, and miR-19a in serum from AMD patients indicate that these miRNAs could potentially serve as diagnostic AMD biomarkers. All three miRNAs significantly correlated with AMD pathogenesis. The discovery of new AMD miRNA may act as biomarkers in evaluating AMD diagnosis and prognosis. The discovery of new AMD