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Metalloporphyrin and gold nanoparticles (AuNPs) were fixed on the surface of hollow zeolite imidazole framework-8 (HZIF-8) by cation exchange and cross-linking reaction. The obtained hybrid nanozyme, Au/HZIF-8@TCPP(Fe), was fully characterized by TEM, HRTEM, EDS element mapping and XPS. Then, its peroxidase-like activity was explored with Km of 1.74 mM and Vmax of 9.60 × 10-8 M·S-1 towards H2O2, indicating excellent catalytic activity. Based on cascade reaction between choline oxidase and Au/HZIF-8@TCPP(Fe), a quick colorimetric method