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Recommendations aligned with each of the four IOM key messages are offered. As a profession, nursing has a responsibility to expand the progress made in addressing substance use - from prevention and early intervention to tertiary care. Nurses at all levels of education and practice are in key positions to carry out the recommendations herein to accelerate the changes needed to provide high quality care for persons impacted by substance use. As a profession, nursing has a responsibility to expand the progress made in addressing substan