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heterogeneous fibroblasts that can form subsets exhibiting different effects on osteoclastogenesis. The subset which depending on the autocrine effects of EDA+FN on VEGF-A, mainly contributes to the osteoclastogenesis and bone destruction of radicular cysts. The regulation of the proportion of subsets is a possible strategy for artificially interfering with osteoclastogenesis. This article is protected by copyright. All rights reserved.An efficient enantioselective construction of tetrahydronaphthalene-1,4-diones as well as dihydrona