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We then performed solitary variant connection screening making use of whole genome-sequencing data for the book composite phenotype in order to identify hereditary loci that donate to disease heterogeneity. Distinct LOAD subtypes were identified for all three research cohorts (two in ROSMAP, three in Mayo Clinic, and two in Mount Sinai mind Bank). Solitary variant organization analysis identified a genome-wide significant variant in TMEM106B (p-value less then 5×10