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To perform a cross-cultural adaptation into Italian and to analyse reliability and validity of the Transsexual Voice Questionnaire for male-to-female transsexuals (I-TVQ ). Cross-sectional nonrandomized survey study. For item-generation, a cross-cultural adaptation and translation process was performed following standard guidelines. Transgender women were consecutively recruited and asked to fill out the I-TVQ and a form on social, demographic and transition-related variables. Firstly, data collected from participants were used to perform