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We here discuss immune cellular markers that will donate to clinical decision-making and may be well worth to standardize in multicenter collaborations for future studies.Background and Aim Sepsis is a very common reason for pediatric intensive treatment unit (ICU) entry. Sepsis-associated encephalopathy (SAE) may occur owing to brain dysfunction in those clients and may also be related to impaired cerebral microcirculation. Transcranial Doppler (TCD) can be used to detect t