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Does ADHD Medication Work? When someone receives a prescription for ADHD medication, they usually be concerned about whether the medication will be effective and how long it will last. Here are some easy answers. Stimulants alter brain chemicals that send messages about attention and activity. They include dopamine and norepinephrine. They are the first-line option for adults with ADHD. 1. Stimulants Stimulants are commonly used t