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How Does ADHD Medication Work? ADHD is treated by taking stimulants. They regulate the levels of two brain chemicals (neurotransmitters) which transmit messages between neurons to improve attention and reduce hyperactivity. 20 percent of people are not sensitive to stimulants such as methylphenidate or amphetamine. This could be due to the chemistry of their bodies or other drugs they are taking. What are the signs of ADHD? If you suspect that your child may have ADHD, start by seeing