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Nevertheless, their particular conclusions were inconsistent, and no systematic review or meta-analysis has-been conducted until now. This meta-analysis was performed to examine potential dose-response relationship between DII rating and UADT disease threat. MATERIAL AND PRACTICES A systematic search had been carried out for appropriate studies in PubMed and online of Science up to March 28, 2019. Categorical meta-analysis along with linear and non-linear dose-response meta-analysis were carried out t