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Phrase of nrf2 in the synovial tissues and FLS was analyzed by immunohistochemistry, real-time PCR, Western blotting, and immunofluorescence staining. Cell proliferation had been analyzed by Cell Counting Kit-8. Cell invasion was tested by transwell assay. Phosphorylation of JNK had been decided by Western blotting. The results showed that nrf2 appearance into the RA synovial cells was upregulated. TNF-α presented expression and nuclear translocation of . Our results might