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Only one study suggested that khat is unrelated to cancer. CONCLUSION RoB and OHAT approach are reliable systematic tools to evaluate plant risk to cancer and provide objective and uniform summary regardless of the study type. In conclusion, our pooled analysis did not find a direct relationship between khat and cancer but anti-cancer effect would require to be proofed on human studies.BACKGROUND AND AIM Breast cancer is the most prevalent cancer in women. To date, regional differences in breast cancer risk factors have not been identif