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Objective This research is conducted to clarify whether the action of low-power diode pumping solid state (DPSS) laser doses modify proteins of normal human blood serum in vitro. Background data Low-power laser light is considered to act through biostimulation rather than through thermal effects. It was found that low-power laser light biostimulates various biological processes, such as increasing the blood flow within the microcirculation. Methods Human blood serum samples were carefully collected and divided into five equal aliquots. O