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nce of LDH following PELD. The risk of recurrence may be effectively reduced with the use of alternative surgical techniques in high risk cases. A large cohort of patients underwent long-term monitoring, and 11 risk factors were verified for assessing each patient's risks before surgery to predict the postoperative recurrence of LDH following PELD. The risk of recurrence may be effectively reduced with the use of alternative surgical techniques in high risk cases.The mitogen-activated protein kinase pathway is one of the most frequently altered pathways in