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This study investigated the relationship between soil TM pollution and anthropogenic activities, thus providing a scientific basis for controlling soil TM pollution at a large-scale level.Alzheimer's disease (AD) is a progressive neurodegenerative disorder with growing major health impacts, particularly in countries with aging populations. The examination of neural circuit mechanisms in AD mouse models is a recent focus for identifying new AD treatment strategies. We hypothesize that age-progressive changes of both long-range and local