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, linearity (2-64μg/mL), accuracy (99%) and precision (%RSD1%) were well in accord with regulatory requirements. Further, analyte was detected at 1μg/mL and was stable over applied stress conditions. In a nutshell, the novel approach produced an accurate method for estimation of palbociclib in tablets with optimum method performance. In a nutshell, the novel approach produced an accurate method for estimation of palbociclib in tablets with optimum method performance.Ketoprofen is a widely used NSAID which incurs gastric mucosal