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To build up a highly effective mucoadhesive medicine distribution system with a targeted release in bacterial infection site, RFX-loaded chitosan (CS)/carboxymethyl-chitosan (CMCS) nanogel had been created and methodically assessed. FTIR, DSC, and XRD demonstrated that the nanogel had been formed by communications between the positively charged NH3+ on CS and CMCS, and also the negatively charged COO on CMCS. RFX had been encapsulated to the enhanced nanogel in amorpho