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Ovariectomy of 10-week-old female Mpig6b-/- mice prevented the introduction of medullary hole osteosclerosis, whereas orchiectomy of male Mpig6b-/- mice didn't exacerbate their particular disease. Significantly, ovariectomized female Mpig6b-/- mice also demonstrated enhancement in spleen body weight in comparison to sham-operated Mpig6b-/- mice, developing estrogen as a contributing aspect towards the seriousness regarding the megakaryocyte-driven osteoscl