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Our multifunctional nanomedicine of GEM and OMe-PS-miR-519c offers a novel therapeutic strategy to treat desmoplasia and hypoxia-induced chemoresistance in pancreatic cancer.Direct foaming from solids is the most efficient method to fabricate porous materials. However, the ideal foaming fails to prepare aerogel of nanoparticles because the plasticity of their solids is denied by the overwhelming interface interactions. Here, we invent a hydroplastic foaming method to directly convert graphene oxide solids into aerogel bulks and microarr