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When perceived changes in course occur, individuals can be left feeling disconnected from who they were in the past. This sensation of being 'off-course' in life is an individual difference we call 'derailment.' In this article, we review derailment's unique contribution to the psychological literature, the role of perceived self and identity change in mental health, and the nuanced association between derailment and depression. Although depression has been emphasized in research to date, we argue for derailment's role in other types o