https://www.selleckchem.com/pr....oducts/mdl-28170.htm
Histidine is much more effective than aspartate in coordinating Zn2+ in the S3-S4 linker. A simple Hodgkin Huxley model of NpHV 1 suggests a decrease of the opening rate if it is inhibited by zinc or cadmium. Limiting slope measurements and high resolution clear native gel electrophoresis (hrCNE) confirmed that NpHV 1 functions as a dimer. The data supports the hypothesis that zinc is coordinated in between the dimer instead of the monomer. Zinc coordination sites may be potential targets for drug development. This article is protecte
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