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To assess the association between glycaemic variability (GV) and type 1 retinopathy of prematurity (ROP) in infants with birth weights of less than 1251 grams. A case-control study of infants with birth weights of less than 1251g who developed type 1 ROP (n=2 was conducted. Controls had a less severe ROP or no eye disease and were individually matched for gestational age and birth weight (n=4. Odds ratios of ROP were calculated based on multiple factors including oxygen exposure, respiratory support, incidence of hyperglycaemia, and