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Data on the effectiveness and security of this utilization of methylprednisolone for customers with serious COVID-19 remain limited. In this retrospective research, epidemiological, medical, laboratory, treatment and results information of hospitalized patients with severe COVID-19 in Zhongnan Hospital of Wuhan University from January 1 to 7 March 2020, were collected. Binary logistic regression model was used to analyse danger elements for condition progression from extreme COVID-19 diseas