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Polymorphisms in the tumor necrosis factor superfamily 15 ( ) gene contribute to susceptibility to inflammatory bowel disease (IBD). However, associations between rs6478109, rs7869487, and rs7865494 polymorphisms and IBD remain unclear. Eligible articles were retrieved from the PubMed, EMBASE, Web of Science, and CNKI databases through 20 March 2020. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the relationships of polymorphisms with IBD susceptibility. Under the recessive model, rs6478109 was