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05). There was a significant decrease in plasma level of VEGF in EOPE and LOPE patients compared to the controls (P 0.05). The proliferation, migration and tube formation ability of HUVECs were enhanced after transfection with pCDH-ghrelin. Ghrelin increased VEGF by activating the Jagged1/Notch2 pathway. Our study uncovered that ghrelin has the potential to improve endothelial function by promoting angiogenesis through Jagged1/Notch2/VEGF pathway. Our study uncovered that ghrelin has the potential to improve endothelial function by
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