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ly, showed hours per day of NIV use was a significant factor associated with survival. CONCLUSIONS The subjects with an OSS score of 4 tolerated NIV and survived significantly longer than subjects with an OSS score of less then 4. An OSS score of 1 signaled NIV intolerance and the need for hospice or transition to planned tracheostomy. Use of OSS can help guide NIV management decisions. Copyright © 2020 by Daedalus Enterprises.BACKGROUND Individuals who share the same comorbidity profile are usually similar with regard to their disease s