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Unexpectedly, we discovered that the main paths of power kcalorie burning, including glycolysis, the tricarboxylic acid period, and electron transportation sequence, tend to be coordinately induced in the transcriptional amount in mid-pupae and maintained into adulthood, and this response is partly dependent on dERR, resulting in the metabolic flaws noticed in mutants. Our data offer the model that dERR plays a role in a transcriptional switch during pupal d