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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression Untreated ADHD can cause chronic underachievement and depression. This is particularly relevant when they fail to achieve their professional and personal goals. It can be difficult to make when there are commonalities in symptoms between ADHD and depression. Identifying the symptoms is a good first step in seeking treatment. 1. Feelings of inadequateness Many people who suffer from untreated ADHD or depression that co-occurs ar