https://www.selleckchem.com/pr....oducts/aebsf-hcl.htm
BACKGROUND Bcl6 is required for the development of T follicular helper and regulatory (Tfh, Tfr) cells that regulate germinal center responses. Bcl6 also impacts the function of regulatory T (Treg) cells. OBJECTIVE The goal of this study is to define the functions of Bcl6 in Treg cells including Tfr cells in the context of allergic airway inflammation (AAI). METHODS We employed a model of house dust mite (HDM) sensitization to challenge wild type, Bcl6fl/fl Foxp3-Cre and Prdm1(Blimp1)fl/fl Foxp3-Cre mice to study the reciprocal roles
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