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6 and 4.7mm, which outperforms the state of the art SVR method[1]. Our results show the efficiency of the proposed registration pipeline, which has potential to improve the robustness and accuracy of intraoperative patient registration. Our results show the efficiency of the proposed registration pipeline, which has potential to improve the robustness and accuracy of intraoperative patient registration.Copper is one of the most ubiquitous environmental pollutants worldwide. Previous studies have focused on the toxicology of high copper e