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01). The difference in 3-year OS (72% vs. 79%, p=0.12) was not statistically significant. The proportion of prospectively enrolled patients was 23% for point-A studies and 33% for volume-based studies. There was no difference in late grade 3 or higher gastrointestinal (3% vs. 4%, p=0.76) genitourinary toxicities (3% vs. 3% p=0.45) between the two groups. Volume-based BT results in superior 3-year DFS and 3-year LC. In the absence of randomized trials, this meta-analysis provides the best evidence regarding transition to 3D planning. Vol