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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression When a person suffers from both ADHD and depression or anxiety, treating the first can usually help the second. Mental health professionals typically prescribe antidepressants or stimulants for depression along with an ADHD medication. Wellbutrin (bupropion) and Effexor, (venlafaxine), are the two most commonly used antidepressants that are prescribed for ADHD "off-label". These drugs increase the level