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the ability to overcome the suffering of pain and reduce the level of depression. Geriatr Gerontol Int 2020; 20 1234-1240. Substance use disorder (SUD) is characterized by compulsive use of addictive substances with considerable impact on both the medical system and society as a whole. The craving of substances leads to relapse in the majority of patients within one year of traditional treatments. In recent decades, neuromodulation approaches have emerged as potential novel treatments of SUD, but the ideal neural target remains contentio
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