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Tricyclic antidepressants (TCAs) are a drug class that were first released to the market in 1959 as a pharmacotherapy for major depressive disorder (MDD). Today, TCAs are Food and Drug Administration (FDA) approved to treat a variety of illnesses, depending on the formulation. TCAs that have FDA approval to treat MDD include amitriptyline, amoxapine, doxepin, desipramine, nortriptyline, protriptyline, imipramine, and trimipramine. Clomipramine is FDA approved for obsessive-compulsive disorder (OCD) in ages ten and older.Histamine is one