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Somatic mutation occurs in half of unilateral primary aldosteronism (PA) and is associated with more severe phenotype. Mutation status can only be identified by tissue sample from adrenalectomy. NP-59 adrenal scintigraphy is a noninvasive functional study for disease activity assessment. This study aimed to evaluate the predictive value of NP-59 adrenal scintigraphy in somatic mutation among PA patients who received adrenalectomy. Sixty-two PA patients who had NP-59 adrenal scintigraphy before adrenalectomy with available mutation status