Causes of Truck Crash Accidents When a truck crash happens, the driver may be at fault, but there are other factors that can cause an accident. The most frequent factors include driver fatigue or impaired driving, as well as trucks loaded with hazardous cargo. Manufacturers of such equipment may be held accountable for damages. In any event medical attention must be sought as soon as you can, and you should see your primary care physician if you have any injuries. You should keep a record of the incident and share details with the other party