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01) and increased the spatial dispersions of S (COV-S ) (WT 0.28 ± 0.03, Rgs5 0.53 ± 0.08, 0.01). Compared with WT heart, Rgs5 increased the induced S1-S2 interval at all sites of heart and widened the window of vulnerability of ventricular tachyarrhythmia ( 0.05). Our findings indicate that Rgs5 is an important regulator of ventricular tachyarrhythmia in mice by prolonging ventricular repolarization and increasing spatial dispersion in ventricle. Our findings indicate that Rgs5-/- is an important regulator of ventricular tachy