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Through RNA pull-down, RNA immunoprecipitation, and necessary protein synthesis assay, the procedure of YTHDF1 regulating Foxm1 ended up being investigated. Then, Foxm1 was inhibited by thiostrepton, and cellular proliferation had been recognized. In vivo, mice received a tail vein injection of adenovirus containing si-YTHDF1 and had been confronted with hypoxia treatment. Pulmonary vascular modifications, right ventricular systolic force (RVSP), and genetics concerning