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This analysis aims to talk about the analysis results linked to the biological results and mechanisms of action of lichen depsides and tridepsides. Probably the most studied element is atranorin, accompanied by gyrophoric acid, diffractaic acid, and lecanoric acid. Antioxidant, cytotoxic, and antimicrobial tasks are one of the most investigated tasks, mainly in in vitro studies, with periodic in silico as well as in vivo researches. Clinical trials have not been carried out ma