https://www.selleckchem.com/pr....oducts/opicapone.htm
Exposure to chronic hyperglycemia due to diabetes mellitus can lead to the development and progression of diabetic kidney disease (DKD). We have recently reported that reduced superoxide production is associated with mitochondrial dysfunction in the kidneys of mouse models of type 1 DKD. We also demonstrated that humans with DKD have significantly reduced levels of mitochondrion-derived metabolites in their urine. Here, we examined renal superoxide production in a type 2 diabetes animal model, the db/db mouse, and the role of a mitoch
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