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This book mutation lead to a substitution of arginine by tryptophan, leading to antithrombin opposition (ATR). Our study is consistent with formerly posted reports. In closing, this research not just identifies a novel mutation of F2 and can donate to the genetic diagnosis and counseling of households with thrombosis but additionally implies that the site p.R541 of F2 may play a vital role in thrombosis. Copyright © 2020 Tang, Zhang, Xie, Jin, Luo, Deng, L